YM-543 choline

CAT: 0931-MF-0144788-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0144788-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1610007-47-0
Target
Others|||SGLT
Related Pathways
Others|||GPCR/G Protein
Bioactivity
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK/Ay type 2 diabetic mice, effects that were sustained even after 12 h.
Smiles
C[N+](C)(C)CC[O-].OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2cc3cccccc3c2)ccc1O
Molecular Formula
C28H37NO7
Molecular Weight
499.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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