(E/Z) -NiCur

• Description :

  (E/Z) -NiCur is the active isomer of NiCur (HY-139149) . (E/Z) -NiCur is a potent CBP histone acetyltransferase (HAT) inhibitor[1].

• CAS Number :

  [63476-70-0]

• UNSPSC :

  12352005

• Target :

  Histone Acetyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-z-nicur.html

• Smiles :

  N#CC1=CC=CC(/C=C2C(/C(CCC/2)=C/C3=CC(C#N)=CC=C3)=O)=C1

• Molecular Formula :

  C22H16N2O

• Molecular Weight :

  324.38

• References & Citations :

  [1]Vincek AS, et al. Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules. 2018;23 (8) :1930. Published 2018 Aug 2.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported