MK-8457

• Description :

  MK-8457 is a dual SYK/ZAP70 inhibitor. MK-8457 can be used for research of rheumatoid arthritis[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Syk

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mk-8457.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H]1C(C)(C)C[C@](C2=NC=C(C3=CC(NC4=NC=CC(C(F)(F)F)=N4)=CC(C)=C3)S2)(O)CC1)O

• Molecular Formula :

  C24H25F3N4O3S

• Molecular Weight :

  506.54

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Coffey G, et al. PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. J Clin Pharmacol. 2017 Feb;57 (2) :194-210.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1312518-84-5]