RegisterLogin

MK-8457

CAT: 0804-HY-112319Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-112319Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MK-8457 is a dual SYK/ZAP70 inhibitor. MK-8457 can be used for research of rheumatoid arthritis[1].
CAS Number
[1312518-84-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mk-8457.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1C(C)(C)C[C@](C2=NC=C(C3=CC(NC4=NC=CC(C(F)(F)F)=N4)=CC(C)=C3)S2)(O)CC1)O
Molecular Formula
C24H25F3N4O3S
Molecular Weight
506.54
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Coffey G, et al. PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. J Clin Pharmacol. 2017 Feb;57 (2) :194-210.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Related Products

CatalogName
HY-P990487-01Anti-PDGFB Antibody (MOR-8457)
HY-123323-01MK-0434
HY-18277MK-7145
HY-100275MK-3328
HY-10301-01MK-3207
HY-120322MK-0969
HY-12819MK-1421
HY-P991229-01MK-4721
HY-W727728MK-8666
HY-P0038MK-852

Alternative Products

CatalogName
T86906-01MK-8457
C00394-01Anti-PDGFB (MOR-8457)
048569PDGFB (MOR-8457) discontinued
F1785-1Anti-PDGFB Antibody (MOR-8457)
M00348-1Anti-PDGFB Reference Antibody (MOR-8457)
BIO0060SM-1mgAnti-human PDGFB (MOR-8457 Biosimilar)
DHB91201Research Grade Anti-Human PDGFB (MOR-8457)
A136593Anti-PDGFB (MOR-8457) Biosimilar (Monoclonal, IgG)
324068-01MK
167912Midkine (MK, MK1, MK-1, MK 1) discontinued

Popular Products