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KPNA6 rabbit pAb

CAT: 0855-ES15271-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15271-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Description
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008],
UniProt
O60684
Swiss Prot
O60684
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human KPNA6 AA range: 404-454
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IP
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Nucleus, nuclear pore, nucleoplasm, cytoplasm, cytosol, membrane
Other Product Names
Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Gene ID (Human)
23633

UniProtKB · O60684

Importin subunit alpha-7

IMA7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60684
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KPNA6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RDC7, D3DPP5, Q5VVU3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Host-virus interactionProtein transportTransport

Domain

Repeat

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