PROTAC SOS1 degrader-5

• UNSPSC Description:

  PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM[1].

• Target Antigen:

  PROTACs; Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-sos1-degrader-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC2=C(C=C(C(OC)=C2)OCC3(CN(C(CCCCCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)C)CC3)C(N[C@@H](C7=CC(N)=CC(C(F)(F)F)=C7)C)=N1

• Molecular Weight:

  872.93

• References & Citations:

  [1]Pang X, et al. Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo. J Med Chem. 2024 Jan 25;67(2):1563-1579.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2836273-61-9