PROTAC SOS1 degrader-5

PROTAC SOS1 degrader-5

• CAS Number: 2836273-61-9
• UNSPSC Description: PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM[1].
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-sos1-degrader-5.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=NC2=C(C=C(C(OC)=C2)OCC3(CN(C(CCCCCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)C)CC3)C(N[C@@H](C7=CC(N)=CC(C(F)(F)F)=C7)C)=N1
• Molecular Weight: 872.93
• References & Citations: [1]Pang X, et al. Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo. J Med Chem. 2024 Jan 25;67(2):1563-1579.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported