PROTAC EGFR degrader 5

• CAS Number:

  2409793-36-6

• UNSPSC Description:

  PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].

• Target Antigen:

  Apoptosis; EGFR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-egfr-degrader-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O)=O)O)=O

• Molecular Weight:

  1070.33

• References & Citations:

  [1]Hao Zhang, et al. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 1;189:112061.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported