Chlorhexidine-d8

CAT: 0804-HY-W738281Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W738281Size:1 Each
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Description
Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248) [1]. Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) [1][2][3].
CAS Number
[1246816-96-5]
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial; Isotope-Labeled Compounds; Necroptosis
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1NC(NC(NCCCCCCNC(NC(NC2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)=N)=N)=N)=N
Molecular Formula
C22H22D8Cl2N10
Molecular Weight
513.50
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-236.|[2]Faria G, et al. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. J Endod. 2007 Jun;33 (6) :715-22.|[3]Zhang J, et al. Pulmonary Toxicity Assessment after a Single Intratracheal Inhalation of Chlorhexidine Aerosol in Mice. Toxics. 2023 Nov 7;11 (11) :910.|[4]Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17 (4) :182-185.|[5]Ribeiro DA, et al. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res. 2004 Oct;39 (5) :358-61.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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