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Chlorhexidine (acetate hydrate)

CAT: 0804-HY-B1248ASize: 1 EachDry Ice: NoHazardous: No
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Description
Chlorhexidine acetate hydrate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine acetate hydrate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine acetate hydrate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine acetate hydrate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) [1][2][3].
CAS Number
206986-79-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H371-H410
Target
Antibiotic; Apoptosis; Bacterial; Necroptosis
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/chlorhexidine-acetate-hydrate.html
Solubility
10 mM in DMSO
Smiles
N=C(NC1=CC=C(Cl)C=C1)NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N.CC(O)=O.CC(O)=O.[x].O
Molecular Formula
C22H30Cl2N10.2C2H4O2.xH2O
Precautions
P260-P264-P270-P273-P280-P302+P352-P305+P351+P338-P308+P311-P330-P362+P364-P391-P405-P501
References & Citations
[1]Faria G, et al. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. J Endod. 2007 Jun;33 (6) :715-22.|[2]Zhang J, et al. Pulmonary Toxicity Assessment after a Single Intratracheal Inhalation of Chlorhexidine Aerosol in Mice. Toxics. 2023 Nov 7;11 (11) :910.|[3]Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17 (4) :182-185.|[4]Ribeiro DA, et al. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res. 2004 Oct;39 (5) :358-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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