Chlorhexidine (diacetate) (Standard)

• Description:

  Chlorhexidine diacetate (Standard) is the analytical standard of Chlorhexidine diacetate (HY-W013699) . This product is intended for research and analytical applications. Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) [1][2][3].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Apoptosis; Bacterial; Necroptosis; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Apoptosis; Others

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/chlorhexidine-diacetate-standard.html

• Smiles:

  N=C(NC1=CC=C(Cl)C=C1)NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N.CC(O)=O.CC(O)=O

• Molecular Formula:

  C26H38Cl2N10O4

• Molecular Weight:

  625.55

• References & Citations:

  [1]Faria G, et al. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. J Endod. 2007 Jun;33 (6) :715-22.|[2]Zhang J, et al. Pulmonary Toxicity Assessment after a Single Intratracheal Inhalation of Chlorhexidine Aerosol in Mice. Toxics. 2023 Nov 7;11 (11) :910.|[3]Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17 (4) :182-185.|[4]Ribeiro DA, et al. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res. 2004 Oct;39 (5) :358-61.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  56-95-1