PF-1163A

• UNSPSC Description:

  PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL[1][2].

• Target Antigen:

  Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/pf-1163a.html

• Smiles:

  O=C(O[C@@H](CC[C@@H](CCCCC(N1C)=O)C)C[C@@H](O)CCC)[C@@H]1CC2=CC=C(C=C2)OCCO

• Molecular Weight:

  477.63

• References & Citations:

  [1]Nose H, et al. PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. J Antibiot (Tokyo). 2002 Nov;55(11):969-74.|[2]Okabe M, et al. Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans. J Nat Prod. 2016 Apr 22;79(4):1208-12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  258871-59-9