7-Hydroxyflavone

• UNSPSC Description:

  7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway[1][2].

• Target Antigen:

  ERK; Keap1-Nrf2

• Type:

  Natural Products

• Related Pathways:

  MAPK/ERK Pathway;NF-κB;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/7-hydroxyflavone.html

• Purity:

  99.84

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13

• Molecular Weight:

  238.24

• References & Citations:

  [1]Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5(5):e01749.|[2]Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  6665-86-7