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7-Hydroxyflavone

CAT: 0804-HY-N7108-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7108-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC) -associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active[1][2][4].
CAS Number
6665-86-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; COX; Enterovirus; ERK; Keap1-Nrf2; Lipoxygenase; Pyruvate Kinase; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-hydroxyflavone.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13
Molecular Formula
C15H10O3
Molecular Weight
238.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5 (5) :e01749.|[2]Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12 (6) :e0179777.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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