7-Hydroxyflavone

• Description:

  7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC) -associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active[1][2][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; COX; Enterovirus; ERK; Keap1-Nrf2; Lipoxygenase; Pyruvate Kinase; Virus Protease

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/7-hydroxyflavone.html

• Concentration:

  10mM

• Purity:

  99.89

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C (C2=CC=CC=C2) OC3=CC (O) =CC=C13

• Molecular Formula:

  C15H10O3

• Molecular Weight:

  238.24

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5 (5) :e01749.|[2]Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12 (6) :e0179777.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  6665-86-7