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6-Hydroxyflavone

CAT: 0804-HY-N7110-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7110-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABAA) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role[1][2][3][4][5][6].
CAS Number
6665-83-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Akt; ERK; GABA Receptor; JNK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-hydroxyflavone.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13
Molecular Formula
C15H10O3
Molecular Weight
238.24
Precautions
H315, H319
References & Citations
[1]Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.|[2]Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.|[3]Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10 (3) :e0116409.|[4]Din ZU, et al. The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity. Histol Histopathol. 2020 Oct;35 (10) :1197-1209.|[5]Ren L, et al. GABA (A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochem Pharmacol. 2010 May 1;79 (9) :1337-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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