Aβ-IN-7

• Description :

  Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/aβ-in-7.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1

• Molecular Formula :

  C14H10N2S

• Molecular Weight :

  238.31

• References & Citations :

  [1]Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported