Aβ-IN-7

Aβ-IN-7

• UNSPSC Description: Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].
• Target Antigen: Amyloid-β
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aβ-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1
• Molecular Weight: 238.31
• References & Citations: [1]Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported