Aβ-IN-7

• UNSPSC Description:

  Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aβ-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1

• Molecular Weight:

  238.31

• References & Citations:

  [1]Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported