BMS-605541

CAT: 0804-HY-120640-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120640-01Size:5 mg
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Description
BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].
CAS Number
[639858-32-5]
UNSPSC
12352005
Target
PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-605541.html
Purity
99.57
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=C(C=C(C(F)=C1)C(NC2CC2)=O)NCC3=CN=C(S3)NC4=NC=CC=C4
Molecular Formula
C19H17F2N5OS
Molecular Weight
401.43
References & Citations
[1]Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5- ((2- (pyridin-2-ylamino) thiazol-5- ylmethyl) amino) benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49 (13) :3766-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

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