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(-) -U-50488 (hydrochloride)

CAT: 0804-HY-15997-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15997-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -U-50488 hydrochloride ((-) -Trans- (1S,2S) -U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-) -U-50488 hydrochloride is a more active enantiomer than (+) trans- (1R,2R) U-50488 or the (±) trans-racemic mixture U-50488 (HY-15997B). (-) -U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM).
CAS Number
114528-79-9
Product Name Alternative
(-) -Trans- (1S,2S) -U-50488 (hydrochloride)
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/minus-u-50488-hydrochloride.html
Purity
99.71
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl
Molecular Formula
C19H27Cl3N2O
Molecular Weight
405.79
References & Citations
[1]Kirti Kumari Sharma, et al. The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning. Forensic Toxicol. 2019;37 (1) :1-16.|[2]Anthony S Zannas, ET AL. Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice. Psychopharmacology (Berl) . 2017 Mar;234 (6) :913-923.|[3]C C Chao, et al. U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages. Drug Alcohol Depend. 2001 Apr 1;62 (2) :149-54.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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