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(S) -Baclofen

CAT: 0804-HY-B0007B-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0007B-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Baclofen is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values ​​of 1.77 μM for GABAB and 1564 μM for GABAA. (S) -Baclofen can be used in research on muscle disorders such as spasticity[1][2].
CAS Number
66514-99-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-baclofen.html
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H](C1=CC=C(C=C1)Cl)CN)O
Molecular Formula
C10H12ClNO2
Molecular Weight
213.66
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Froestl W, et al. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995;38 (17) :3297-3312.|[2]He Q, et al. Simultaneous Quantitation of S (+) - and R (-) -Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 8;25 (2) :250.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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