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Baclofen (Standard)

CAT: 0804-HY-B0007R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0007R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Baclofen (Standard) is the analytical standard of Baclofen. This product is intended for research and analytical applications. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].
CAS Number
1134-47-0
UNSPSC
12352005
Target
GABA Receptor; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/baclofen-standard.html
Smiles
O=C(O)CC(C1=CC=C(Cl)C=C1)CN
Molecular Formula
C10H12ClNO2
Molecular Weight
213.66
References & Citations
[1]Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74 (1) : p. 89-96.|[2]Mehdi Farokhnia, et al. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Mol Psychiatry. 2018 Oct 31.|[3]Woori Kim, et al. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :706-11.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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