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Baclofen-d4

CAT: 0804-HY-B0007SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0007SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Baclofen-d4 is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].
CAS Number
1189938-30-4
UNSPSC
12352005
Hazard Statement
H330
Target
GABA Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Purity
99.98
Solubility
10 mM in DMSO|DMSO : 4.81mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C) |H2O : 2mg/mL (ultrasonic)
Smiles
OC(CC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)CN)=O
Molecular Formula
C10H8D4ClNO2
Molecular Weight
217.69
Precautions
H330
References & Citations
[1]Woori Kim, et al. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :706-11.|[2]Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74 (1) : p. 89-96.|[3]Mehdi Farokhnia, et al. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Mol Psychiatry. 2018 Oct 31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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