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Baclofen

CAT: 0804-HY-B0007-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0007-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].
CAS Number
1134-47-0
UNSPSC
12352005
Hazard Statement
H301
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Baclofen.html
Purity
99.98
Solubility
0.1 M HCl : 10 mg/mL (ultrasonic) |DMSO : 4.76 mg/mL (ultrasonic; warming; adjust pH to 4 with 1 M HCL; heat to 60°C) |H2O : 2 mg/mL (ultrasonic)
Smiles
O=C(O)CC(C1=CC=C(Cl)C=C1)CN
Molecular Formula
C10H12ClNO2
Molecular Weight
213.66
Precautions
H301
References & Citations
[1]Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74 (1) : p. 89-96.|[2]Mehdi Farokhnia, et al. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Mol Psychiatry. 2018 Oct 31.|[3]Woori Kim, et al. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :706-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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