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Baclofen (hydrochloride)

CAT: 0804-HY-B0007C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0007C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Baclofen hydrochloride, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen hydrochloride mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen hydrochloride has high blood brain barrier penetrance. Baclofen hydrochloride has the potential for muscle spasticity research[1][2][3].
CAS Number
28311-31-1
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/baclofen-hydrochloride.html
Purity
99.78
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL
Smiles
O=C(CC(CN)C1=CC=C(C=C1)Cl)O.Cl
Molecular Formula
C10H13Cl2NO2
Molecular Weight
250.12
Precautions
H315, H319, H335
References & Citations
[1]Woori Kim, et al. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :706-11.|[2]Mehdi Farokhnia, et al. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Mol Psychiatry. 2018 Oct 31.|[3]Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74 (1) : p. 89-96.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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