JAK3-IN-14
CAT:
804-HY-155951-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JAK3-IN-14
- CAS Number: 454234-24-3
- UNSPSC Description: JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].
- Target Antigen: JAK
- Type: Reference compound
- Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/jak3-in-14.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C1NC2=CC=C(C3=CN=CC=C3)C=C2/C1=C/C4=CC=CN4
- Molecular Weight: 287.32
- References & Citations: [1]Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported