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JAK3-IN-12

CAT: 0804-HY-147975Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147975Size:1 Each
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Description
JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].
CAS Number
1430095-86-5
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak3-in-12.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(OC1=CC=C(NC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)C=C1)=O
Molecular Formula
C19H19N5O4S
Molecular Weight
413.45
References & Citations
[1]Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3

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