JAK3-IN-12
CAT:
804-HY-147975
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JAK3-IN-12
- CAS Number: 1430095-86-5
- UNSPSC Description: JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].
- Target Antigen: JAK
- Type: Reference compound
- Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/jak3-in-12.html
- Solubility: 10 mM in DMSO
- Smiles: CS(=O)(OC1=CC=C(NC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)C=C1)=O
- Molecular Weight: 413.45
- References & Citations: [1]Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported