JAK3-IN-9

JAK3-IN-9

• CAS Number: 1430095-30-9
• UNSPSC Description: JAK3-IN-9 is an orally active JAK3 inhibitor with IC50 value of 1.7 nM. JAK3-IN-9 is highly selective to the JAK3 signal path. JAK3-IN-9 is lowly toxic with high oral bioavailability, shows good anti-arthritis activity. JAK3-IN-9 can be used in autoimmune disease research[1].
• Target Antigen: JAK
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/jak3-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)[C@@H](C)NC1=C(C(N)=O)C=NC(NC2=CC=C(OS(=O)(C)=O)C=C2)=N1
• Molecular Weight: 393.46
• References & Citations: [1]Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported