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Hypericin-d10

CAT: 0804-HY-N0453S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0453S-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Apoptosis; Influenza Virus; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Cancer
Purity
95.32
Solubility
DMSO : 250 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(O)C([2H])=C(O)C3=C2C4=C(C5=C6C(O)=C([2H])C(C([2H])([2H])[2H])=C5C7=C4C1=C(O)C([2H])=C7C([2H])([2H])[2H])C8=C3C(O)=C([2H])C(O)=C8C6=O
Molecular Formula
C30H6D10O8
Molecular Weight
514.50
Precautions
H302, H317
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34 (3) :221-41.|[3]Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90 (1) :158-62.|[4]Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21 (4A) :2649-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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