Hypericin

• Description:

  Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450) . Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H317

• Target:

  Antibiotic; Apoptosis; Cytochrome P450; Dopamine β-hydroxylase; Influenza Virus; Monoamine Oxidase; PKC; Reverse Transcriptase; Telomerase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Hypericin.html

• Purity:

  98.03

• Solubility:

  DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O

• Molecular Formula:

  C30H16O8

• Molecular Weight:

  504.44

• Precautions:

  H302, H317

• References & Citations:

  [1]A Kubin, et al. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11 (2) :233-53.|[2]A Popovic, et al. Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. J Photochem Photobiol B. 2015 Aug;149:249-56.|[3]Renata Sanovic, et al. Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. Photodiagnosis Photodyn Ther. 2011 Dec;8 (4) :291-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• CAS Number:

  [548-04-9]