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Hypericin

CAT: 0804-HY-N0453-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0453-01Size:1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450) . Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].
CAS Number
[548-04-9]
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Antibiotic; Apoptosis; Cytochrome P450; Dopamine β-hydroxylase; Influenza Virus; Monoamine Oxidase; PKC; Reverse Transcriptase; Telomerase
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Hypericin.html
Purity
98.03
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O
Molecular Formula
C30H16O8
Molecular Weight
504.44
Precautions
H302, H317
References & Citations
[1]A Kubin, et al. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11 (2) :233-53.|[2]A Popovic, et al. Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. J Photochem Photobiol B. 2015 Aug;149:249-56.|[3]Renata Sanovic, et al. Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. Photodiagnosis Photodyn Ther. 2011 Dec;8 (4) :291-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3

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