Piperin-d10

CAT: 0804-HY-W654320Size: 2.5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W654320Size:2.5 mg
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Description
Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3][4].
Product Name Alternative
Bioperine-d10; 1-Piperoylpiperidine-d10
UNSPSC
12352005
Target
Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; P-glycoprotein
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(N1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])/C=C/C=C/C2=CC=C3OCOC3=C2
Molecular Formula
C17H9D10NO3
Molecular Weight
295.40
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3 (1) :9. Epub 2015 Oct 29.|[3]Meghwal M, et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27 (8) :1121-30.|[4]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.|[5]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TRC-P483002-2.5MGPiperin-d10
019791Piperin
165959Piperin-d5
TRC-T344256-5MGThiobencarb-d10 (diethyl-d10)
R100004Raloxifene-d10 (piperidine-d10)
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MBS6117550-01Lidocaine-d10 Hydrochloride (2-(Diethyl-d10-amino)-N-(2,6-dimethylphenyl)acetamide Hydrochloride, Basicaina-d10, Batixim-d10, Dynexan-d10, Heweneural-d10, Licain-d10)
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