TDHL-d10

• Description:

  TDHL-d10 (Tergurid-d10; Terguride-d10; trans-Dihydrolisuride-d10) is the deuterium labeled TDHL (HY-12714) . TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

• Product Name Alternative:

  Tergurid-d10; Terguride-d10; trans-Dihydrolisuride-d10

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(N[C@@H]1CN([C@]([H])(CC2=CNC3=C2C4=CC=C3)[C@@]4(C1)[H])C)N(C([2H])(C([2H])([2H])[2H])[2H])C([2H])(C([2H])([2H])[2H])[2H]

• Molecular Formula:

  C20H18D10N4O

• Molecular Weight:

  350.52

• References & Citations:

  [1]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[2]Mizokawa T, et al. Terguride as a new anti-hyperprolactinemic agent: characterization in rats and dogs in comparison with bromocriptine. Jpn J Pharmacol. 1993 Nov;63 (3) :269-78.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported