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Phenytoin-d10

CAT: 0804-HY-B0448SSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0448SSize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
CAS Number
65854-97-9
Product Name Alternative
5,5-Diphenylhydantoin-d10
UNSPSC
12352005
Hazard Statement
H225, H301+H311+H331, H370
Target
Isotope-Labeled Compounds; Sodium Channel; Virus Protease
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Field of Research
Cancer; Neurological Disease
Purity
99.50
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)
Smiles
O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O
Molecular Formula
C15H2D10N2O2
Molecular Weight
262.33
Precautions
H225, H301+H311+H331, H370
References & Citations
[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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