Phenytoin-d10

• Description :

  Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

• Product Name Alternative :

  5,5-Diphenylhydantoin-d10

• UNSPSC :

  12352005

• Hazard Statement :

  H225, H301+H311+H331, H370

• Target :

  Isotope-Labeled Compounds; Sodium Channel; Virus Protease

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel; Others

• Field of Research :

  Cancer; Neurological Disease

• Purity :

  99.50

• Solubility :

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

• Smiles :

  O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O

• Molecular Formula :

  C15H2D10N2O2

• Molecular Weight :

  262.33

• Precautions :

  H225, H301+H311+H331, H370

• References & Citations :

  [4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [65854-97-9]