PD-L1-IN-7

PD-L1-IN-7

• CAS Number: 3024733-03-4
• UNSPSC Description: PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC50: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/pd-l1-in-7.html
• Smiles: CC1=C(C=CC=C1C2=NC3=CC(CN([C@@H]4CC[C@H](CC4)C(O)=O)C)=CC(C#N)=C3O2)C5=C6C(N(C7=CC(OC)=C(C(OC)=C7)CN([C@H]8[C@H](COCC8)O)C)N=C6)=CC=C5
• Molecular Weight: 798.93
• References & Citations: [1]Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported