ML-211

ML-211

• CAS Number: 2205032-89-7
• UNSPSC Description: ML-211 is a carbamate-based dual inhibitor of acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) (IC50=17 nM) and LYPLA2 (IC50=30 nM). ML-211 also inhibits theserine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases[1].
• Target Antigen: MAGL; Phospholipase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/ml-211.html
• Purity: 98.06
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1CCC(C(C)(C)C)CC1)N2N=CC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2
• Molecular Weight: 418.53
• References & Citations: [1]Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013).
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported