ML-211

• Description :

  ML-211 is a carbamate-based dual inhibitor of acyl-protein thioesterase 1 (APT1) /lysophospholipase 1 (LYPLA1) (IC50=17 nM) and LYPLA2 (IC50=30 nM) . ML-211 also inhibits theserine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases[1].

• UNSPSC :

  12352005

• Target :

  MAGL; Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ml-211.html

• Purity :

  99.42

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CCC(C(C)(C)C)CC1)N2N=CC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2

• Molecular Formula :

  C25H30N4O2

• Molecular Weight :

  418.53

• References & Citations :

  [1]Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) . Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013) .

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2205032-89-7]