PhAc-ALGP-Dox

CAT: 0804-HY-P10760Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10760Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells[1].
CAS Number
[1616592-31-4]
UNSPSC
12352209
Target
Peptide-Drug Conjugates (PDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phac-algp-dox.html
Smiles
OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC([C@H]6N(CCC6)C(CNC([C@H](CC(C)C)NC([C@H](C)NC(CP(O)(O)=O)=O)=O)=O)=O)=O
Molecular Formula
C45H58N5O19P
Molecular Weight
1003.94
References & Citations
[1]Andrea Casazza, et al. PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index. Mol Cancer Ther. 2022 Apr 1;21 (4) :568-581.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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