Dox-btn2

• Description:

  Dox-btn2 is a biotin labeled Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm[1].

• Product Name Alternative:

  Biotin Labeled Doxorubicin

• UNSPSC:

  12352005

• Target:

  ADC Payload; AMPK; Antibiotic; Apoptosis; Autophagy; Bacterial; HBV; HIV; Mitophagy; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/dox-btn2.html

• Purity:

  97.42

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C1C2=C (O) C3=C ([C@H] (C[C@] (C (CO) =O) (C3) O) O[C@H]4C[C@H] (NC (CCOCCOCCOCCOCCNC (CCCC[C@H]5[C@@]6 ([H]) NC (N[C@]6 (CS5) [H]) =O) =O) =O) [C@H] (O) [C@H] (C) O4) C (O) =C2C (C7=C1C=CC=C7OC) =O

• Molecular Formula:

  C48H64N4O18S

• Molecular Weight:

  1017.10

• References & Citations:

  [1]Yu Z, et al. Chem-map profiles drug binding to chromatin in cells. Nat Biotechnol. 2023 Jan 23.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3026061-31-1