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PF 00337210

CAT: 0804-HY-16387Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16387Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-00337210 is a potent and selective inhibitor of VEGFRs, designed for treating age-related macular degeneration via intravitreal injection. The formulation strategy focused on developing an ophthalmic solution that would precipitate upon injection into the vitreous, ensuring sustained drug delivery. Challenges included maintaining low dosing volumes, selecting safe excipients for intravitreal use, and addressing the drug's unique physicochemical properties. The final formulation, an isotonic solution in a citrate-buffered vehicle with NaCl, demonstrated stability, potency, and recovery through intravitreal dosing syringes. It formed a depot upon injection into vitreous humor, representing a novel nonpolymeric in situ-forming depot formulation for intravitreal drug delivery[1].
CAS Number
854514-88-8
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pf-00337210.html
Smiles
O=C(C1=C(C)OC2=CC(OC3=CC=NC4=CC(OCCN5CCOCC5)=CC=C34)=CC=C12)NC
Molecular Formula
C26H27N3O5
Molecular Weight
461.51
References & Citations
[1]PF 00337210
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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