ML-184

• Description :

  ML-184 (CID244033) is a selective GPR55 agonist with an EC50 of 250 nM, more than 100-fold selectivity for GPR55 over GPR35, CB1, and CB2. ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55. ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro[1][2][3].

• Product Name Alternative :

  CID2440433

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  GPR55

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ml-184.html

• Purity :

  99.57

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1=CC=CC(N2CCN(CC2)C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)=C1C

• Molecular Formula :

  C25H34N4O3S

• Molecular Weight :

  470.63

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50 (25) :5633-47.|[2]Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175 (16) :3407-3421.|[3]Corbett Reece, et al. Once-daily oral administration of gpr55 agonist ml-184 has direct and indirect benefits on [beta]-cell and gastrointestinal health in obese-diabetic mice. Endocrine Abstracts. Vol. 104. Bioscientifica, 2024.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [794572-10-4]