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EGFR-IN-184

CAT: 0804-HY-179148Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179148Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-184 is an EGFR inhibitor (IC50 = 65.6 nM) . EGFR-IN-184 has anti proliferative activity against various tumor cells, such as T47D (IC50 = 15 μM), PC3 (IC50 = 55 μM), HCT116 (IC50 = 36 μM) cells. EGFR-IN-184 can significantly induce cell apoptosis and block the cell cycle. EGFR-IN-184 can be used for research on various types of cancer[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=CC2=C(N=C(S2)NC(CN3C=C(N=N3)COC(C4=CC=C(C=C4)Cl)=O)=O)C=C1
Molecular Formula
C20H16ClN5O3S
Molecular Weight
441.89
References & Citations
[1]Alsehli M, et al. Click synthesis of some novel benzo[d]thiazole-1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer. RSC Med Chem. 2025 Sep 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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