CB-184

CAT: 0804-HY-14220Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-14220Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2].

CAS Number

[165307-47-1]

UNSPSC

12352005

Target

Apoptosis; Sigma Receptor

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cb-184.html

Smiles

OC1=CC=CC([C@@]2(CCN3C)CC(/C([C@H]3C2)=C/C4=CC(Cl)=C(Cl)C=C4)=O)=C1

Molecular Formula

C22H21Cl2NO2

Molecular Weight

402.31

References & Citations

[1]Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18 (7) :938-49.|[2]Keith W Crawford, et al. sigma (2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443 (1-3) :207-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS387875-01	CB-184
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A13512-10	CB-184 10mg
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CB-184

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