CB-184

• Description:

  CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cb-184.html

• Smiles:

  OC1=CC=CC ([C@@]2 (CCN3C) CC (/C ([C@H]3C2) =C/C4=CC (Cl) =C (Cl) C=C4) =O) =C1

• Molecular Formula:

  C22H21Cl2NO2

• Molecular Weight:

  402.31

• References & Citations:

  [1]Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18 (7) :938-49.|[2]Keith W Crawford, et al. sigma (2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443 (1-3) :207-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  165307-47-1