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HPK1 Assay Kit

CAT: 0421-79775Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-79775Size:96 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HPK1 (MAP4K1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. It is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76, suggesting HPK1 could be a novel target for anti-tumor immunotherapy.
Description
The HPK1 Assay Kit is designed to measure HPK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.MBP (Myelin Basic Protein) is a non-specific protein substrate that is used as a "universal substrate" for many in-vitro kinase activity assays.  This protein is targeted by many serine/threonine kinases at conserved amino acids. We use the dephosphorylated version of the MBP substrate in our assays to determine the kinase-mediated phosphorylation of MBP.  Our assays are not suitable for studying autophosphorylation of the kinase due to the presence of the MBP substrate.
UniProt
Q92918
Format
Catalog #ComponentsAmountStorage40398HPK13 µg-80°CAvoid freeze/ thaw cycles!793345x Kinase assay buffer1.5 ml-20°C79686ATP (500 µM) 100 µl-20°CMBP (5 mg/ml) 200 µl-20°C7969696-well plate, white1Room Temp.
Shipping Conditions
-80°C
Storage Conditions
Up to 6 months when stored as recommended

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