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PF-07957472

CAT: 0804-HY-169092-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169092-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM) . PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model[1].
CAS Number
3041047-51-9
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-07957472.html
Purity
99.13
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(N2CCN(CC2)C)=CC=C1C)NC3(CC3)C4=C5C=CC=CC5=NC(C6=CN(C)N=C6)=C4
Molecular Formula
C29H32N6O
Molecular Weight
480.60
References & Citations
[1]Garnsey MR, et al. Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model. Sci Adv. 2024 Aug 30;10 (35) :eado4288.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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