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Batefenterol (Succinate)

CAT: 0804-HY-12980ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12980ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Batefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD) [1].
CAS Number
945905-37-3
Product Name Alternative
GSK961081 (Succinate) ; TD-5959 (Succinate)
UNSPSC
12352005
Target
Adrenergic Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/batefenterol-succinate.html
Smiles
OC(CCC(O)=O)=O.COC(C=C(C(Cl)=C1)NC(CCN2CCC(CC2)OC(NC3=C(C4=CC=CC=C4)C=CC=C3)=O)=O)=C1CNC[C@@H](C5=C6C(NC(C=C6)=O)=C(C=C5)O)O
Molecular Formula
C44H48ClN5O11
Molecular Weight
858.33
References & Citations
[1]Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351 (1) :190-9.|[2]Hughes AD, et al. Discovery of (R) -1- (3- ((2-chloro-4- (((2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl) amino) methyl) -5-methoxyphenyl) amino) -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol) : first-in-class dual pharmacology multivalent muscarinic antagonist and β? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) . J Med Chem. 2015 Mar 26;58 (6) :2609-22.|[3]Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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