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Diethyl succinate

CAT: 0804-HY-Y0836-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0836-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2].
CAS Number
123-25-1
Product Name Alternative
Diethyl Butanedioate
UNSPSC
12352211
Hazard Statement
H319, H402
Target
Biochemical Assay Reagents; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diethyl-succinate.html
Purity
99.99
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(OCC)CCC(OCC)=O
Molecular Formula
C8H14O4
Molecular Weight
174.19
Precautions
H319, H402
References & Citations
[1]Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1- (13) C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134 (2) :934-43.|[2]Lixiang Wang, et al. "Diethyl succinate modulates microglial polarization and activation by reducing mitochondrial fission and cellular ROS." Metabolites 11.12 (2021) : 854.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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