Batefenterol (Standard)

• Description :

  Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081; TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

• CAS Number :

  [743461-65-6]

• UNSPSC :

  12352100

• Target :

  Adrenergic Receptor; mAChR; Reference Standards

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Smiles :

  O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)=O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

• Molecular Formula :

  C40H42ClN5O7

• Molecular Weight :

  740.24

• References & Citations :

  [1]Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351 (1) :190-9.|[2]Hughes AD, et al. Discovery of (R) -1- (3- ((2-chloro-4- (((2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl) amino) methyl) -5-methoxyphenyl) amino) -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol) : first-in-class dual pharmacology multivalent muscarinic antagonist and β? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) . J Med Chem. 2015 Mar 26;58 (6) :2609-22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards