Batefenterol

CAT: 0804-HY-12980-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-12980-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Batefenterol (GSK961081; TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

CAS Number

743461-65-6

Product Name Alternative

GSK961081; TD-5959

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Batefenterol.html

Purity

99.72

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)=O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Molecular Formula

C40H42ClN5O7

Molecular Weight

740.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351 (1) :190-9.|[2]Hughes AD, et al. Discovery of (R) -1- (3- ((2-chloro-4- (((2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl) amino) methyl) -5-methoxyphenyl) amino) -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol) : first-in-class dual pharmacology multivalent muscarinic antagonist and β? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) . J Med Chem. 2015 Mar 26;58 (6) :2609-22.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

MAChR2; mAChR3

Alternative Products

Catalog	Name
BA5116-10	Batefenterol
A21387-50	Batefenterol 50mg
A21387-100	Batefenterol 100mg
A21387-5	Batefenterol 5mg
GTR19211607-01	Batefenterol Succinate
A21387-25	Batefenterol 25mg

Batefenterol

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