Batefenterol

• Description :

  Batefenterol (GSK961081; TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

• Product Name Alternative :

  GSK961081; TD-5959

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adrenergic Receptor; mAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Batefenterol.html

• Purity :

  99.72

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)=O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

• Molecular Formula :

  C40H42ClN5O7

• Molecular Weight :

  740.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351 (1) :190-9.|[2]Hughes AD, et al. Discovery of (R) -1- (3- ((2-chloro-4- (((2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl) amino) methyl) -5-methoxyphenyl) amino) -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol) : first-in-class dual pharmacology multivalent muscarinic antagonist and β? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) . J Med Chem. 2015 Mar 26;58 (6) :2609-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  MAChR2; mAChR3

• CAS Number :

  [743461-65-6]