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Mouse CD11b Antibody / MAC-1 / ITGAM

CAT: 0800-R32580Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32580Size:100 µg
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Description
Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (aM/b2) molecule, also known as macrophage-1 antigen (Mac-1) or cluster of differentiation molecule 11b (CD11b) . It is mapped to 16p11.2. ITGAM/CD11b has a role in vascular repair after mechanical arterial injury. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. What's more, ITGAM probably recognizes the R-G-D peptide in C3b, and it is also a receptor for fibrinogen, factor X and ICAM1.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Gene ID
16409
UniProt
P05555
Host
Rabbit
Reactivity
Mouse
Immunogen
A mouse recombinant protein corresponding to amino acids E260-T360 was used as the immunogen for the mouse CD11b antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the mouse CD11b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This mouse CD11b antibody is available for research use only.
Storage Conditions
After reconstitution, the mouse CD11b antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the mouse CD11b antibody should be determined by the researcher.
Location
Cell membrane, cytoplasm
Image Legend
Western blot testing of mouse 1) brain and 2) HEPA lysate with mouse CD11b antibody at 0.5ug/ml. Expected molecular weight: 127~170 kDa due to glycosylation.

UniProtKB · P05555

Integrin alpha-M

ITAM_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P05555
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Itgam
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8CA73
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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