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CD11b Antibody / MAC-1 / ITGAM

CAT: 0800-RQ5356Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5356Size:100 µL
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Description
The ITGAM gene encodes the integrin alpha M chain, also called CD11b and MAC-1. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P11215
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide specific to human CD11b / ITGAM was used as the immunogen for the CD11b antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
GC-9
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CD11b antibody at -20oC.
Limitations
This CD11b antibody is available for research use only.
Storage Conditions
Store the CD11b antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CD11b antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human spleen tissue with CD11b antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P11215

Integrin alpha-M

ITAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11215
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q4VAK0, Q4VAK1, Q4VAK2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionImmunityInnate immunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Systemic lupus erythematosus

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GTR18571976CD11b Antibody / MAC-1 / ITGAM
BNUM3338-50CD11b / MAC-1 (Microglial Marker) (ITGAM/3338), 1mg/mL
BNUM3339-50CD11b / MAC-1 (Microglial Marker) (ITGAM/3339), 1mg/mL
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GTR18575000CD11b Antibody / MAC-1
BNUB0271-500CD11b / MAC-1 (Microglial Marker) (ITGAM/271), 0.2mg/mL
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