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CD11b Antibody / MAC-1 / ITGAM

CAT: 0800-R31044Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31044Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITGAM (Integrin Alpha-M), also called CD11b, MAC-1 or Mo1 alpha subunit (MO1A), is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (alphaMbeta2) molecule. A major surface antigen family on human leukocytes includes complement receptor type 3 (CR3A; also called ITGAM, Mac1, or Mo1), lymphocyte function-associated (LFA) antigen type 1 (ITGAL), and p150, 95 (ITGAX) . By in situ hybridization, Corbi et al. (1988) demonstrated that the genes encoding the alpha subunits of LFA1 (ITGAL), Mac1, and p150, 95 (ITGAX), all of which are involved in leukocyte adhesion, constitute a cluster on 16p13.1-p11. Callen et al. (1991) narrowed the assignment to 16p11.2. Inflammation plays an essential role in the initiation and progression of atherosclerosis. Simon et al. (2000) presented evidence that it also has a role in vascular repair after mechanical arterial injury (i.e., percutaneous transluminal coronary angioplasty, or PTCA) .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P11215
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human CD11b (MEQLKKSKTLFSLMQY) was used as the immunogen for this CD11b antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CD11b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD11b antibody is available for research use only.
Storage Conditions
After reconstitution, the CD11b antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CD11b antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell membrane, cytoplasm
Image Legend
Western blot testing of CD11b antibody and Lane 1: Jurkat; 2: Raji; Observed molecular weight: 127~170 kDa due to glycosylation.

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