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TLR7 Antibody

CAT: 0800-R32339Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32339Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLR7 (Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunocytochemistry: 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
Q9NYK1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids QAHPYFWQCLKNALATDNHVAYSQVFKE of human TLR7 were used as the immunogen for the TLR7 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F, ICC, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the TLR7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TLR7 antibody is available for research use only.
Storage Conditions
After reconstitution, the TLR7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TLR7 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) MCF7, 2) COLO320 and 3) Jurkat lysate with TLR7 antibody. Expected/observed molecular weight ~121 kDa.

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