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TLR9 Antibody

CAT: 0800-RQ7107Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7107Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
Q9NR96
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Amino acids SRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKD were used as the immunogen for the TLR9 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the TLR9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TLR9 antibody is available for research use only.
Storage Conditions
After reconstitution, the TLR9 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TLR9 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human spleen tissue with TLR9 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q9NR96

Toll-like receptor 9

TLR9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NR96
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLR9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B3Y661, D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Biological process

ImmunityInflammatory responseInnate immunity

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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