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Integrin alpha 4 Antibody / ITGA4

CAT: 0800-R31960Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31960Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITGA4/Integrin alpha4 is an integrin alpha subunit. It makes up half of the alpha4beta1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. ITGA4 is also mapped to 2q31-q32 by fluorescence in situ hybridization.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P13612
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Amino acids MWKAGFFKRQYKSILQEENRRDSWSYINSK of human ITGA4 were used as the immunogen for the Integrin alpha 4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Integrin alpha 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Integrin alpha 4 antibody is available for research use only.
Storage Conditions
After reconstitution, the Integrin alpha 4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Integrin alpha 4 antibody should be determined by the researcher.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of 1) rat liver, 2) rat kidney, human 3) Jurkat, 4) 22RV1, 5) HepG2, 6) SMMC lysate with Integrin alpha 4 antibody. Predicted molecular weight ~115 kDa, routinely observed at ~150 kDa; observed here at ~220 kDa.

UniProtKB · P13612

Integrin alpha-4

ITA4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13612
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DPG4, Q7Z4L6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

IntegrinReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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