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ITGA5 Antibody / Integrin alpha 5

CAT: 0800-RQ5245Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5245Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000
UniProt
P08648
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide specific to human Integrin alpha 5 / ITGA5 was used as the immunogen for the ITGA5 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
IDB-9
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the ITGA5 antibody at -20oC.
Limitations
This ITGA5 antibody is available for research use only.
Storage Conditions
Store the ITGA5 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the ITGA5 antibody should be determined by the researcher.
Image Legend
Western blot testing of mouse heart lysate with ITGA5 antibody. Expected molecular weight: 115-160 kDa depending on glycosylation level. An ~25 kDa band corresponding to the ITGA5 light chain may also be detected.

UniProtKB · P08648

Integrin alpha-5

ITA5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08648
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q96HA5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

Host cell receptor for virus entryIntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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