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ITGA4 Antibody / Integrin alpha 4

CAT: 0800-RQ5406Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5406Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ITGA4 gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P13612
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Integrin alpha 4 / ITGA4 was used as the immunogen for the ITGA4 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
IHH-9
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the ITGA4 antibody at -20oC.
Limitations
This ITGA4 antibody is available for research use only.
Storage Conditions
Store the ITGA4 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the ITGA4 antibody should be determined by the researcher.
Image Legend
Western blot testing of human Jurkat cell lysate with ITGA4 antibody. Predicted molecular weight ~115 kDa, routinely observed at ~150 kDa.

UniProtKB · P13612

Integrin alpha-4

ITA4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13612
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DPG4, Q7Z4L6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

IntegrinReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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